Medication Search: Triazolam
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How does this medication work? What will it do for me?
Triazolam belongs to the class of medications called benzodiazepines. It is used for the short-term (usually no more than 7 to 10 days) relief of sleep disturbances. It can be helpful for people who have difficulty falling asleep. Triazolam is not recommended for early morning awakenings.
What form(s) does this medication come in?
Each pale blue, oval, flat-faced, bevelled-edged, scored tablet, identified "APO" over "0.25", contains 0.25 mg of triazolam. Nonmedicinal ingredients: croscarmellose sodium, FD&C Blue No. 2 Aluminum Lake, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.
How should I use this medication?
The recommended dose of triazolam ranges from 0.125 mg to 0.25 mg taken before bedtime. The starting dose is usually 0.125 mg taken immediately before bedtime. The lowest effective dose of the medication should be used. Your doctor may increase the dose if necessary.
This medication should not normally be used for more than 7 to 10 consecutive days as triazolam is habit-forming. If used for more than a few weeks, this medication may lose some of its effectiveness (meaning the dose needs to be increased to have the same effect) and may also cause some dependence.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is several hours later and taking the medication will interfere with your next day’s activities, skip the missed dose and continue with your regular dosing schedule. Do not take more medication than prescribed.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Who should NOT take this medication?
Do not take this medication if you:
- are allergic to triazolam or any ingredients of this medication
- are pregnant
- have a history of substance or alcohol abuse
- have myasthenia gravis
- have severe breathing difficulties
- have sleep apnea
- have uncorrected narrow-angle glaucoma
What side effects are possible with this medication?
- clumsiness or unsteadiness
- dizziness or lightheadedness
- false sense of well-being
- nausea or vomiting
- unusual tiredness or weakness
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- behavioural changes, including:
- angry outbursts
- bizarre behaviour
- decreased inhibition
- depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- hallucinations (hearing or seeing things that aren’t there)
- lack of memory (of events taking place after the medication was taken)
- muscle weakness
- trouble sleeping
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Addiction potential: Triazolam is habit-forming. Withdrawal symptoms similar to those occurring with other benzodiazepines (as well as with alcohol) have been observed after stopping triazolam suddenly when it has been taken regularly over a period of time (more than 2 weeks). These symptoms include:
- abdominal cramps
- extreme anxiety
- memory impairment
- muscle pain
- sleep problems
Alcohol and other medications that cause drowsiness: People taking this medication should not combine it with alcohol and avoid combining it with other medications, such as narcotic pain relievers, that cause drowsiness. Doing so can cause additional drowsiness and reduced breathing as well as other side effects, which can be dangerous and potentially fatal.
Behaviour changes: Using triazolam can cause an increase in daytime anxiety or restlessness. There have also been reports of aggressive behaviour or hostility, anxiousness, disorientation or decreased memory.
As with other medications to help with sleep problems, these effects are more likely to happen to seniors. If you experience any of these effects or notice them in a family member who is taking this medication contact your doctor as soon as possible.
Breathing problems: Triazolam, like many other sedative medications can suppress breathing. If you have asthma, other lung disease, or sleep apnea, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Confusion: This medication may affect mental efficiency (e.g., concentration, attention, and vigilance). The risk of confusion is greater for seniors and for those with brain injury.
Depression or psychosis: Triazolam is not recommended for use by people with depression or psychosis. Abnormal thinking and psychotic behavioural changes have been reported (e.g., aggressiveness). Particular caution is warranted for patients with a history of violent behaviour. If you have a history of mental illness, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Drowsiness/reduced alertness: Avoid performing hazardous activities requiring complete mental alertness, such as driving or operating machinery, until the effects of triazolam wear off. Using alcohol or other drugs that cause drowsiness or sedation is also not recommended.
Complex sleep-related behaviours such as "sleep-driving" (i.e., driving while not fully awake after ingestion of a sedative-hypnotic, with no memory of the event) have been reported by patients who have taken triazolam. The use of alcohol or other medications that cause drowsiness seems to increase the risk of this happening.
Glaucoma: This medication may cause the symptoms of glaucoma (increased pressure in the eye) to worsen. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking this medication.
Kidney function: If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor.
Breast-feeding: It is not known if triazolam passes into breast milk. If you are a breast-feeding mother and are taking this medication it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of triazolam for children below the age of 18 have not been established.
Seniors: The sedative effects of triazolam may affect seniors more than others. Extra caution is needed, for example, when getting up during the night.
What other drugs could interact with this medication?
There may be an interaction between triazolam and any of the following:
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- "azole" antifungals (e.g., ketoconazole, fluconazole, miconazole, voriconazole)
- barbiturates (e.g., phenobarbital, secobarbital)
- other benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- chloral hydrate
- general anesthetics (medications used to put people to sleep before surgery)
- grapefruit juice
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- macrolide antibiotics (e.g., erythromycin, clarithromycin)
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
- narcotics (e.g., codeine, fentanyl, morphine, hydromorphone)
- St. John’s wort
- seizure medications (e.g., carbamazepine, clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
- theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
- tricyclic antidepressants (e.g., clomipramine, desipramine, imipramine)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
All material copyright MediResource Inc. 1996 – 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Triazolam