Learn about many of the available medications in our database.
Tobramycin Inhalation Solution by Sandoz
How does this medication work? What will it do for me?
Tobramycin inhalation belongs to a group of medications called antibiotics, and more specifically to the group called aminoglycosides. It is used for people with cystic fibrosis to treat chronic lung infections caused by certain bacteria. It works by killing the bacteria causing the infection.
What form(s) does this medication come in?
Each 5 mL ampule of sterile, clear, slightly yellow, non-pyrogenic, aqueous solution with the pH and salinity adjusted specifically for administration by a compressed air driven reusable nebulizer contains 300 mg of tobramycin and 11.25 mg of sodium chloride. Nonmedicinal ingredients: sterile water for injection, sulfuric acid, and sodium hydroxide to adjust the pH to 6.0.
How should I use this medication?
For the ampules, the usual dose for adults and children 6 years of age and older is one ampule (300 mg) inhaled twice a day for 28 days. The doses should be used as close to 12 hours apart as possible, and no less than 6 hours apart. After 28 days, this medication should be stopped for the next 28 days and then restarted for the next 28 days.
Each dose should be given with the hand-held reusable nebulizer provided to you. Do not dilute or mix this medication with other medications in the nebulizer. If you are using other medications that require a nebulizer, use them first, then use this medication.
For the capsules, the usual dose for adults and children 6 years of age and older is the contents of 4 capsules inhaled twice a day for 28 days. The doses should be used as close to 12 hours apart as possible, and no less than 6 hours apart. After 28 days, this medication should be stopped for the next 28 days and then restarted for the next 28 days.
The contents of the capsules should only be inhaled with the device that is provided and should not be swallowed. If you are using other inhaled medications, this medication should be used last. If you are using a short-acting bronchodilator (e.g., salbutamol), use it 15 to 90 minutes before inhaling this medication. Always allow the device and capsules to reach room temperature before using. Children, especially those who are 10 years of age or younger, should be provided assistance for using this medication until they are able to use the device properly without help.
The effectiveness of the medication depends on the proper use of the device that delivers the tobramycin. The powder contents of the capsule are intended to be inhaled. Do not swallow the capsules. Have your doctor or pharmacist instruct you in the correct procedure for using the device used to administer the medication, depending on which form of inhaled tobramycin you are using.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose and there is at least 6 hours until the next dose, take it as soon as possible and continue with your regular schedule. Otherwise, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store the ampules in the refrigerator at 2°C to 8°C, protect them from light, and keep them out of the reach of children. If a refrigerator is not available, you can store the pouches (opened or unopened) at room temperature (up to 25°C) for up to 28 days.
The solution in the ampule is slightly yellow, but may darken with age if not stored in the refrigerator; however, the color change does not indicate any change in the quality of the product as long as it is stored within the recommended storage conditions. Do not use this medication if it appears cloudy or there are particles in the solution.
Store the capsules at room temperature in the original package to protect from them moisture, and keep them out of the reach of children. Only remove the capsules from their packaging immediately before use.
Who should NOT take this medication?
Do not use this medication if you:
- are allergic to tobramycin or any ingredients of this medication
- are allergic to other aminoglycosides (e.g., gentamicin)
What side effects are possible with this medication?
- change in sputum colour
- dry mouth
- feeling unwell
- loss of voice
- muscle aches
- runny nose
- sore throat or mouth
- taste changes
- trouble speaking
- voice changes or loss of voice
Check with your doctor as soon as possible if any of the following side effects occur:
- coughing up blood
- ringing in the ears or hearing changes
- skin rash
- wheezing, shortness of breath, or chest tightness
- worsening difficulty breathing
Stop taking the medication and seek immediate medical attention if any of the following occur:
- severe watery or bloody diarrhea
- symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; swelling of the face, mouth, throat, or tongue)
Are there any other precautions or warnings for this medication?
Antibiotic-related diarrhea: As with other antibiotics, tobramycin inhalation can cause a severe form of diarrhea associated with a condition known as pseudomembranous colitis. If you develop severe diarrhea while taking (or within a few weeks of taking) this medication, contact your doctor.
Breathing problems: Occasionally, inhaled medications may cause the airways to spasm and close up, making breathing even more difficult (bronchospasm) and can be life-threatening. If you experience increased difficulty breathing after using a dose of inhaled tobramycin, seek immediate medical attention.
Ear problems: This medication may cause ear problems that appear as decreased hearing, ringing in the ears, dizziness, spinning sensations, or lack of coordination. If you experience any of these symptoms, contact your doctor.
Kidney function: If you have reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Neuromuscular problems: Tobramycin may make symptoms of muscle weakness worse for people with neuromuscular problems. If you have myasthenia gravis, Parkinson’s disease, or similar health problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Resistance: There is a chance that bacteria can become resistant to this medication. If you are not getting better despite using this medication, contact your doctor.
Pregnancy: Like other medications in this class, tobramycin may cause harm to an unborn baby if it is used by the mother during pregnancy. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Tobramycin given by the intravenous (into a vein) route passes into breast milk. It is not known if tobramycin inhalation passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 6 years of age.
Seniors: The safety and effectiveness of using this medication have not been established for seniors.
What other drugs could interact with this medication?
There may be an interaction between tobramycin inhalation and any of the following:
- aminoglycosides given by injection (e.g., tobramycin, gentamicin)
- amphotericin B
- BCG vaccine
- bisphosphonates (e.g., alendronate, etidronate)
- botulinum toxins
- loop diuretics (e.g., ethacrynic acid, furosemide)
- non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
All material copyright MediResource Inc. 1996 – 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Tobramycin-Inhalation-Solution-by-Sandoz