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How does this medication work? What will it do for me?
Valproic acid belongs to the class of medications called anticonvulsants. It is used to manage and control certain types of seizures. It works on the central nervous system (CNS) in the brain to reduce the number and severity of seizures.
What form(s) does this medication come in?
ratio-Valproic is no longer being manufactured for sale in Canada. For brands that may still be available, search under valproic acid. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.
How should I use this medication?
The recommended dose of valproic acid is based on body weight. The dose of medication is usually started at a low level (15 mg per kg of body weight per day) to minimize side effects, and increased gradually until seizures are controlled with a minimum of side effects. The maximum recommended dose is 60 mg per kg of body weight per day.
The capsules should be swallowed whole. Do not chew or puncture the capsules. Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons. Valproic acid may be taken with food or on an empty stomach, however taking this medication with food may help to reduce stomach upset.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Who should NOT take this medication?
Do not take valproic acid if you:
- are allergic to valproic acid or any ingredients of the medication
- have liver disease or significant reduction in liver function
- have Alpers syndrome or Alpers-Huttenlocher syndrome, conditions caused by nervous system breakdown
- have porphyria
- have certain metabolic disorders (urea cycle disorders)
Valproic acid should not be used by pregnant women if there is a suitable alternative medication.
What side effects are possible with this medication?
Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abdominal or stomach cramps (severe)
- changes in hair (hair loss or increased hair on face, chest, and back)
- hallucinations (seeing or hearing things that aren’t there)
- increase in seizures
- decreased level of consciousness, increasing tiredness and weakness with behaviour changes (extreme irritability, combativeness)
- nausea or vomiting (continuing)
- signs of bleeding (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of muscle damage (e.g., muscle pain, tenderness or weakness, or brown or discoloured urine) – especially if you also have a fever or a general feeling of being unwell
- urinary incontinence
Seek immediate medical attention if any of the following occur:
- signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
- symptoms of a serious allergic reaction, including angioedema (e.g., hives; swelling of the face, mouth, hands, or feet; and difficulty breathing)
- signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
- thoughts of self-harm
Are there any other precautions or warnings for this medication?
Blood clotting: This medication may make it more difficult for the blood to clot. If you take anticoagulant (blood thinning) medications, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Take appropriate precautions and ensure that all doctors involved in your care are aware of all medication use. Tests for blood clotting should take place before any surgery. Platelet count and coagulant tests should take place before starting treatment with valproic acid.
Drowsiness/reduced alertness: Valproic acid may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how this medication affects you.
Hypersensitivity syndrome: A severe allergic reaction called hypersensitivity syndrome has occurred for some people with the use of valproic acid. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.
Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: Liver failure has occurred infrequently for people taking valproic acid, usually during the first 6 months of treatment. Children under 2 years of age who take valproic acid together with other epilepsy medications are at greatest risk (nearly 20 times greater) of developing serious liver problems. These children typically have other medical conditions such as congenital metabolic disorders, severe seizure disorders accompanied by mental retardation, or organic brain disease. Liver function tests should take place before starting treatment with valproic acid.
Symptoms that can occur before serious liver problems include seizure control, malaise, weakness, lethargy, loss of appetite, and vomiting. People who take valproic acid should tell their doctor at once if they experience these symptoms. Increases in the levels of ammonia in the blood, with or without lethargy or coma, have been reported and may be present despite normal liver function tests.
Pancreatitis: Cases of life-threatening pancreatitis (inflammation of the pancreas) have been reported for both children and adults. This can occur at any time during the use of valproic acid. If you experience signs of pancreatitis such as abdominal pain on the upper left side, back pain, loss of appetite, nausea, fever, chills, rapid heartbeat, or swollen abdomen contact your doctor immediately.
Sedation: Valproic acid may cause sedation, especially when combined with another sedating drug such as alcohol.
Seizures: Some people experience an increase in seizures or new types of seizures when taking valproic acid. If you experience a change in your seizures, contact your doctor as soon as possible.
Stopping the medication: Valproic acid should not be stopped suddenly, as this can cause seizures to increase in frequency and severity. If you need to stop taking this medication, it should be reduced gradually. Talk to your doctor about the best way to stop this medication.
Suicidal thoughts: There is a small risk that this medication may result in thoughts of suicide. If you experience these symptoms or any other behaviour change while taking this medication, contact your doctor immediately. Family members or caregivers of people who are taking this medication should contact the person’s doctor immediately if they notice unusual behaviour changes.
Pregnancy: There is an increased risk of serious birth defects for a child whose mother takes valproic acid during pregnancy. Valproic acid may cause a defect of the spine called spina bifida, cleft palate, heart defects, autism, or slowed or reduced mental development. Women of child-bearing age must use effective birth control while taking valproic acid.
Before becoming pregnant, women with epilepsy should speak to their doctor about other options for seizure medications. If you become pregnant while taking this medication, contact your doctor immediately.
People who need medications to prevent major seizures should not stop taking them. If it is necessary to stop taking this medication, your doctor will advise you of the best way to reduce or change the medication.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking valproic acid it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. As a general rule, women who are taking valproic acid are advised not to breast-feed.
Children: If valproic acid is given to children 2 years old or younger, it should be used with extreme caution and as a single medication. The benefits of seizure control should be weighed against the risk.
Seniors: People over the age of 65 may be more at risk of developing side effects from this medication and may require lower dosages.
What other drugs could interact with this medication?
There may be an interaction between valproic acid and any of the following:
- aminosalicylic acid
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
- benzodiazepines (e.g., diazepam, lorazepam, clonazepam)
- birth control pills (estrogens)
- bismuth subsalicylate
- estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
- sodium oxybate
- tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/ratio-Valproic