Pegfilgrastim belongs to the family of medications known as granulocyte colony stimulating factors (G-CSF). Pegfilgrastim helps the bone marrow produce white blood cells which help the body fight infection.
Pegfilgrastim is used to treat neutropenia (low counts of a certain type of white blood cell known as neutrophils) for people who have certain types of cancer and are receiving a type of chemotherapy that slows down white blood cell production.
Neulasta® is available in a single-use syringe that contains 6 mg of pegfilgrastim.
Each 0.6 mL single-use syringe of sterile, clear, colourless, preservative-free liquid for subcutaneous administration contains 6 mg of pegfilgrastim (based on protein mass only). Nonmedicinal ingredients: polysorbate 20, sodium acetate, sorbitol, and water for injection, USP; pH: 4.0. The needle cover on the prefilled syringe contains dry natural rubber (a derivative of latex).
The recommended adult dose of pegfilgrastim is 6 mg given by subcutaneous (under the skin) injection after each cycle of chemotherapy. Pegfilgrastim should not be given less than 14 days before chemotherapy and not until 24 hours after chemotherapy.
Pegfilgrastim is usually given under medical supervision. If you are giving pegfilgrastim to yourself, your doctor or health care professional will instruct you on how to use pegfilgrastim properly. It is important to use this medication exactly as prescribed by your doctor.
If you miss a dose of pegfilgrastim, call your doctor.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Do not shake this medication vigorously. Shaking pegfilgrastim damages the medication, making it less effective. This medication should be stored in the refrigerator and protected from light. Freezing should be avoided, but if the medication is accidentally frozen, allow it to thaw in the refrigerator before being given. If the medication is accidentally frozen 2 times or is left at room temperature for more than 72 hours, it should be discarded.
Do not take this medication if you:
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Capillary leak syndrome (CLS): Capillary leak syndrome been experienced by people using pegfilgrastim. This is a condition where blood leaks from the small blood vessels, into your body. CLS can cause severely decreased blood pressure and may be life threatening. If you experience symptoms of CLS, such as swelling or puffiness, difficulty breathing, abdominal swelling, tiredness, feeling of fullness, seek immediate medical attention.
Cytotoxic chemotherapy: The safety of using pegfilgrastim at the same time as cytotoxic chemotherapy (a type of chemotherapy that kills cells, especially cancer cells) has not been established. Pegfilgrastim should not be used within 14 days before or 24 hours after chemotherapy. In addition, it is not known whether it is safe and effective to use pegfilgrastim after certain chemotherapy medications (e.g., mitomycin C, 5-flurouracil, and nitrosoureas such as carmustine and lomustine).
Ruptured spleen: In rare cases, this medication has been reported to cause the spleen to rupture, which can be fatal. The spleen is an organ in the body that is involved in the production and removal of blood cells. If you have pain in the left upper stomach or left shoulder tip area, contact your doctor immediately.
Lung problems: Pegfilgrastim may cause adult respiratory distress syndrome (ARDS), a serious lung condition, when people with neutropenia have sepsis (bacterial infection in the blood). If ARDS occurs, this medication should be stopped until the ARDS resolves.
Radiation: It is not known whether it is safe and effective to use pegfilgrastim with radiation therapy. Pegfilgrastim should not be used during radiation therapy.
Sickle cell disease: Pegfilgrastim may cause sickle cell crisis when used by people who have sickle cell disease. You and your doctor should carefully consider the benefits and risks of using pegfilgrastim in these circumstances.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, stop taking it immediately and call your doctor.
Breast-feeding: It is not known whether pegfilgrastim passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of pegfilgrastim have not been established for children.
There may be an interaction between pegfilgrastim and any of the following:
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Neulasta