This medication is used for the treatment of symptoms for people with mild-to-severe Alzheimer’s disease. Donepezil does not cure Alzheimer’s disease. It works in the brain to improve thinking, memory, attention, and the ability to do simple tasks.
Each white, film coated, round tablet, embossed with "DL" over "5" on one side and "M" on the reverse contains 5 mg of donepezil hydrochloride. Nonmedicinal ingredients: lactose monohydrate, maize starch, hydroxylpropylcellulose, microcrystalline cellulose, and magnesium stearate. Coating: hypromellose, titanium dioxide, and polyethylene glycol.
Each white, film coated, round tablet, embossed with "DL" over "10" on one side and "M" on the reverse contains 10 mg of donepezil hydrochloride. Nonmedicinal ingredients: lactose monohydrate, maize starch, hydroxylpropylcellulose, microcrystalline cellulose, and magnesium stearate. Coating: hypromellose, titanium dioxide, polyethylene glycol, quinoline yellow aluminium lake, and yellow iron oxide.
The recommended initial dose of donepezil is 5 mg once daily. If the response is not adequate after 4 to 6 weeks, your doctor may increase the dose to 10 mg daily, which is the recommended maximum daily dose. For senior women with a low body weight, it is recommended that the dose of donepezil not exceed 5 mg daily. Donepezil can be taken with or without food at the same time every day, in the morning or evening.
The tablet should be swallowed whole with water. The rapidly disintegrating tablet should be placed on the tongue and allowed to dissolve before swallowing with water.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken on a regular schedule as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not take donepezil if you:
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
January 21, 2015
Health Canada has issued new restrictions concerning the use of Aricept (donepezil). To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.
Asthma and lung conditions: If you have lung conditions such as asthma or chronic obstructive pulmonary disease, discuss with your doctor how this medication may affect your medical condition, and whether any special monitoring is needed. Donepezil could cause symptoms of these conditions to worsen.
Chronic illness: In general, people with chronic medical conditions should be cautious when taking donepezil because of the increased risk of side effects. The benefits of taking the medication must be carefully weighed against the risks.
Epilepsy: There is a possibility that donepezil may increase the risk of seizures for susceptible people. If you have a history of seizure disorder, speak to your doctor about the risks and benefits of taking donepezil.
Heart disease: If you have heart disease such as active coronary artery disease or congestive heart failure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Donepezil has the potential to slow the heart rate. People with cardiac conduction abnormalities (e.g., heart rhythm problems such as sick sinus syndrome) should not take donepezil.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Muscle effects: In rare cases, serious muscle damage has been associated with the use of donepezil. Report any unexplained muscle pain, tenderness, weakness or cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or fever.
Neuroleptic malignant syndrome (NMS): Donepezil, can rarely cause a potentially fatal syndrome known as neuroleptic malignant syndrome (NMS). If you notice the symptoms of NMS, get immediate medical attention. Symptoms include high fever, muscle stiffness, confusion or loss of consciousness, sweating, racing or irregular heartbeat, and fainting.
Stomach problems: Donepezil has the potential to cause an increase in the amount of acid that the stomach produces. If you have a history of ulcers or are at increased risk of developing stomach ulcers, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: The safety of donepezil for use during pregnancy has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if donepezil passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
There may be an interaction between donepezil and any of the following:
All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Mylan-Donepezil