Dihydroergotamine belongs to a family of medications called ergot alkaloids. It is used to help relieve the pain of migraine headaches. These medications work by constricting blood vessels in the head. This relieves the dilation (widening) of blood vessels, which is related to migraine headache pain.
Dihydroergotamine is most effective if used at the first sign of a migraine headache with or without aura (warning signs that occur prior to the onset of a migraine headache). It is not effective for other types of headache. Relief is often obtained within one-half hour of using the medication. Extra medication may be given if some relief is not obtained after the initial dose. (See the following section for maximum doses.)
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are using this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
Each mL of clear, colourless to faintly yellow solution contains dihydroergotamine mesylate USP 4 mg. Nonmedicinal ingredients: caffeine, dextrose, and water.
The recommended dose of dihydroergotamine is one spray in each nostril (total of 2 sprays) at the first sign or symptom of a migraine headache, or as early as possible after the onset of migraine headache pain. If the migraine has not improved sufficiently after about 15 minutes, one additional spray can be used in each nostril (total of 2 more sprays).
One bottle of dihydroergotamine nasal spray contains 4 sprays. No more than 4 sprays (2 in each nostril, i.e., one bottle) should be used for any migraine attack. No more than 8 sprays (2 bottles) should be used in any 24-hour period. No more then 24 sprays (6 bottles) should be used in any 7-day period.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important to use this medication exactly as prescribed by your doctor.
The spray should be used in the following manner (see package insert for illustrated details):
Store the product at room temperature.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Do not use dihydroergotamine if you:
There may be other conditions where the doctor may not want you to use this medication. Be sure to tell all health care professionals involved in your care about all your medical conditions.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people using this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Stop using the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using this medication.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Dependence: If you take dihydroergotamine for extended periods of time you may become dependent upon it and require progressively increasing doses for relief of headaches or to prevent the increasing unpleasant effects which may follow withdrawal of the medication.
Drowsiness/reduced alertness: You should not undertake activities requiring mental alertness, such as operating equipment or driving a vehicle, until you determine your response and sensitivity to this medication.
Overdose: It is important to stay within the limits of the recommended dosage of this medication and avoid excessive or prolonged use. An overdose of ergotamine is dangerous, and may cause the following effects:
If an overdose is suspected, seek medical help immediately.
Pregnancy: Dihydroergotamine may cause harm when taken during pregnancy. If you become pregnant while using this medication, contact your doctor immediately.
Breast-feeding: Dihydroergotamine passes into breast milk and may cause symptoms of vomiting, diarrhea, weak pulse, and unstable blood pressure in nursing infants. If you are a breast-feeding mother you should not take this medication.
Children: The safety and effectiveness of this medication for children less than 16 years of age have not been established. It is not recommended for use by children.
There may be an interaction between dihydroergotamine and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Migranal