Medication Search: Lioresal Intrathecal
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How does this medication work? What will it do for me?
Baclofen belongs to two groups of medications known as muscle relaxants and antispastics. It is used to treat spasticity (uncontrolled muscle movements) caused by multiple sclerosis, spinal cord injuries, or spinal cord diseases. It is believed to work mainly by relaxing the muscles.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each mL of clear, colourless solution contains baclofen 0.05 mg for intrathecal administration. Nonmedicinal ingredients: sodium chloride and water for injection.
Each mL of clear, colourless solution contains baclofen 0.5 mg for intrathecal administration. Nonmedicinal ingredients: sodium chloride and water for injection.
Each mL of clear, colourless solution contains baclofen 2 mg for intrathecal administration. Nonmedicinal ingredients: sodium chloride and water for injection.
How should I use this medication?
The recommended dose of the injectable form of baclofen is based on individual needs. Injectable baclofen should only be injected intrathecally (into the fluid space around the spinal cord). Some people will have a special pump implanted under their skin to deliver baclofen to the spinal cord on a continuous basis.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
With long-term use, intrathecal baclofen may become less effective and require higher doses to obtain the same effect as before. If baclofen appears to be less effective, contact your doctor as soon as possible.
It is important that this medication be given exactly as prescribed by your doctor. It is very important to keep your appointments to have the pump refilled, otherwise spasms may recur.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take this medication if you are allergic to baclofen or any ingredients of the medication
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- abdominal or stomach pain or discomfort
- decreased sexual ability
- difficulty sleeping
- dry mouth
- frequent urination
- increased perspiration
- low blood pressure (e.g., fainting, dizziness, lightheadedness, blurred vision, nausea)
- trouble sleeping
Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- breathing problems
- difficulty speaking
- false sense of well-being
- hallucinations (seeing or hearing things that aren’t there)
- loss of coordination
- muscle pain
- nightmares or vivid dreams
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of heart problems (e.g., tiredness, swelling in the legs, shortness of breath)
- signs of urinary tract problems (e.g., decreased urine production, difficulty urinating, bloody or dark urine)
- skin rash or hives
- slow heartbeat
- symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
- tingling or numbness of the hands or feet
- uncontrolled eye movements
- vision changes
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Drowsiness/reduced alertness: Baclofen may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how this medication affects you.
Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. This occurs because baclofen is primarily removed from the body by the kidneys. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Medical conditions: Certain medical conditions may make it more likely for you to experience serious side effects. People with certain types of bladder problems, stomach ulcers, breathing problems, and seniors with cerebrovascular problems (disorder of the blood vessels supplying the brain) should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Mental health: Baclofen may cause symptoms of psychosis or schizophrenia to get worse for people who have mental health problems. If you experience symptoms such as hallucinations, mania (feeling unusually over-excited or uninhibited), or delusional thinking, or notice them in a family member who is taking this medication, contact your doctor as soon as possible.
Seizures: Baclofen may cause a loss of seizure control, causing seizures to occur more often. If you have a history of epilepsy or medical conditions that increase your risk of seizures, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Withdrawal effects: If baclofen is suddenly stopped after regular use, withdrawal symptoms may occur, including:
- anxiety with racing heart and sweating
- hallucinations (seeing and hearing things that aren’t there)
- insomnia (difficulty sleeping)
- involuntary movements
- psychotic, manic, or paranoid states
- worsening of spasticity (loss of control of muscles)
Except when serious side effects occur, the dose should be reduced slowly when stopping the medication (over a period of approximately 1 to 2 weeks).
Pregnancy: The safe use of baclofen during pregnancy has not been established. Baclofen crosses the placental barrier and may affect the developing baby. Babies born to women who have taken baclofen during pregnancy may experience withdrawal symptoms after birth. If you are or may become pregnant, speak to your doctor. This medication should be taken during pregnancy only when the potential benefits outweigh the possible risks.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking baclofen, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safe use of baclofen by children under the age of 12 years has not been established and is not recommended.
Seniors: People over the age of 65 are more likely to experience side effects of taking baclofen. Doses for seniors should generally be lower and increased more slowly than for other adults.
What other drugs could interact with this medication?
There may be an interaction between baclofen and any of the following:
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- antidiabetes medications (e.g., glyburide, insulin)
- barbiturates (e.g., butalbital, phenobarbital)
- benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
- chloral hydrate
- general anesthetics (medications used to put people to sleep for surgery)
- magnesium sulfate
- medications used to treat high blood pressure
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
- other muscle relaxants (e.g., cyclobenzaprine, methocarbamol, orphenadrine)
- narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
- seizure medications (e.g., carbamazepine, clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
- tricyclic antidepressants (e.g., amitriptyline, imipramine)
If you are taking any medications containing this drug, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription) and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or illegal drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Lioresal-Intrathecal