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How does this medication work? What will it do for me?

Efinaconazole belongs to the class of medications called antifungal agents. It is used to treat mild-to-moderate fungal infections of the toenails.

This medication works by blocking the production of a compound known as ergosterol, which is found in the cell walls of fungi. Without ergosterol, the fungi cannot reproduce and eventually they die off.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each mL of clear solution contains 100 mg of efinaconazole. Nonmedicinal ingredients: alcohol, butylated hydroxytoluene, C12-15 alkyl lactate, citric acid, cyclomethicone, diisopropyl adipate, disodium edetate, and purified water.

How should I use this medication?

One drop of efinaconazole is applied to the surface of each affected toenail once a day, preferably at bedtime. If you are treating the big toenail, apply a second drop to the end of the toenail using the tip of the brush.

Before applying the solution to the toenails, wash and dry the affected area. Wait for at least 10 minutes before applying efinaconazole. Use the applicator brush to spread the solution to cover the toenail and the skin immediately around the nail, including the skin underneath the nail. Do not squeeze the bottle while spreading the solution. Allow the solution to completely dry before touching the area with sheets, socks, or other clothing. Wash your hands with soap after applying this medication.

Continue to use this medication for the full length of time recommended by your doctor. If you stop treatment too soon, the infection may return and be harder to treat.

Avoid contact of this medication with eyes, mouth, nose, lips, or open wounds. In the event of accidental contact, rinse thoroughly with water.

Many things can affect the dose of medication that a person needs. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, with the bottle upright and tightly closed. The solution is flammable; keep it away from heat or flame. Protect the medication from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not use this medication if you are allergic to efinaconazole or any ingredients of the medication.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • skin irritation around the toenail (e.g., burning, redness, itching, stinging)

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blisters or crusts around the application site
  • skin rash
  • swollen skin around the affected area

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Health conditions: The safety and effectiveness of this medication have not been determined for people who have conditions in which you can get infections more easily such as diabetes, HIV infections, or a weakened immune system. Discuss any concerns you may have with your doctor.

Hygiene: Toenails should be clipped every four weeks. Clip the unaffected toenails before clipping the affected nails. Discard the clippings and clean the toenail clippers after each use. Do not share your clippers with other people to avoid spreading the infection.

Avoid getting a pedicure from a non-healthcare professional while you are using efinaconazole. Do not use nail polish or other cosmetic products on the toenails while you are using efinaconazole.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if efinaconazole passes into breast milk. If you are breast-feeding and taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with this medication?

This medication is applied topically and not expected to interact with other medications.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

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Last Updated: 15/07/2024