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  • All material © 1996-2015 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.



    Common Name


    How does this medication work? What will it do for me?

    Entacapone belongs to a group of medications called catechol-O-methyl
    transferase (COMT) inhibitors
    . It is used along with levodopa-carbidopa or
    levodopa-benserazide to treat Parkinson’s disease.

    By inhibiting COMT enzymes that normally break down levodopa in the body,
    entacapone increases the amount of levodopa reaching the brain. This reduces
    the end-of-dose “wearing off” effect that some people taking levodopa
    may experience, thereby minimizing fluctuations in symptoms of Parkinson’s
    disease. When taken on its own, entacapone has no effect on symptoms of
    Parkinson’s disease.

    This medication may be available under multiple brand names and/or in
    several different forms.
    Any specific brand name of this medication may not
    be available in all of the forms or approved for all of the conditions
    discussed here. As well, some forms of this medication may not be used for all
    of the conditions discussed here.

    Your doctor may have suggested this medication for conditions other than
    those listed in these drug information articles.
    If you have not discussed
    this with your doctor or are not sure why you are taking this medication, speak
    to your doctor. Do not stop taking this medication without consulting your

    Do not give this medication to anyone else, even if they have the same
    symptoms as you do.
    It can be harmful for people to take this medication if
    their doctor has not prescribed it.

    What form(s) does this medication come in?

    Each brownish-orange, unscored, oval-shaped, film-coated tablet, embossed
    with “COMTAN” on one side, contains entacapone 200 mg. Nonmedicinal
    croscarmellose sodium, hydrogenated vegetable oil, magnesium
    stearate, mannitol, and microcrystalline cellulose; coating: glycerol
    85%, hydroxypropylmethyl cellulose, magnesium stearate, polysorbate 80, red
    iron oxide, sucrose, titanium dioxide, and yellow iron oxide.

    How should I use this medication?

    Entacapone is to be taken together with either levodopa-carbidopa or
    levodopa-benserazide to treat people with Parkinson’s disease who experience
    end-of-dose “wearing off” of levodopa. End-of-dose “wearing
    off” refers to a decrease in the amount of time that levodopa is
    effective, which results in fluctuations in Parkinson’s disease symptoms.

    The recommended dose of entacapone is 200 mg taken with each
    levodopa-carbidopa or levodopa-benserazide dose, up to 8 times daily.

    This medication can be taken with or without food. Swallow the tablets
    whole. Do not crush or chew the tablets.

    This medication has no effect on symptoms of Parkinson’s disease when taken

    Many things can affect the dose of a medication that a person needs, such as
    body weight, other medical conditions, and other medications. If your doctor
    has recommended a dose different from the ones listed here,
    do not change
    the way that you are taking the medication without consulting your doctor.

    It is important to take this medication exactly as prescribed by your
    doctor. If you miss taking a dose of entacapone with your levodopa dose, skip
    that dose and take your next entacapone dose with your next levodopa dose. Do
    not take a double dose to make up for a missed one.
    If you are not sure
    what to do after missing a dose, contact your doctor or pharmacist for advice.

    Store this medication at room temperature, protect it from light and
    moisture, and keep it out of the reach of children.

    Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

    Who should NOT take this medication?

    Do not take entacapone if you:

    • are allergic to entacapone or
      any ingredients of the medication
    • are taking or have taken a
      non-selective monoamine oxidase inhibitor (MAOI) within the last 2 weeks
      (e.g., moclobemide, phenelzine, tranylcypromine)
    • have a previous history of
      neuroleptic malignant syndrome or rhabdomyolysis
    • have liver impairment
    • have pheochromocytoma (a
      tumour in the adrenal glands)
    • have active heart, lung,
      kidney, blood, or hormonal disease
    • have narrow-angle glaucoma
    • have or have had skin lesions
      that may be melanoma
    • have any condition where
      epinephrine, norepinephrine, isoprenaline or dopamine should not be given
    What side effects are possible with this medication?

    Many medications can cause side effects. A side effect is an unwanted
    response to a medication when it is taken in normal doses. Side effects can be
    mild or severe, temporary or permanent.

    The side effects listed below are not experienced by everyone who takes this
    medication. If you are concerned about side effects, discuss the risks and
    benefits of this medication with your doctor.

    The following side effects have been reported by at least 1% of people
    taking this medication. Many of these side effects can be managed, and some may
    go away on their own over time.

    Contact your doctor if you experience these side effects and they are
    severe or bothersome. Your pharmacist may be able to advise you on managing
    side effects.

    • constipation
    • darkened colour of
      sweat, saliva, or urine
    • decrease in weight
    • decreased appetite
    • diarrhea
    • dizziness
    • dry mouth
    • falling
    • fatigue
    • fever
    • headache
    • increased sweating
    • involuntary movements
    • muscle pain or cramps
    • nausea
    • nightmares
    • sensation of spinning
    • tremor
    • trouble sleeping
    • vomiting

    Although most of these side effects listed below don’t happen very often,
    they could lead to serious problems if you do not check with your doctor or
    seek medical attention.

    Check with your doctor as soon as possible if any of the following side
    effects occur:

    • chest pain
    • excessive daytime
    • difficult urination
    • hallucinations
      (hearing or seeing things that aren’t there)
    • sexual dysfunction
    • signs of colitis
      (inflammation of the digestive tract; persistent diarrhea, abdominal
    • signs of depression
      (e.g., changes in sleeping or appetite, loss of interest in activities,
      poor concentration, feelings of guilt)
    • signs of liver
      problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight
      loss, yellowing of the skin or whites of the eyes, dark urine, pale
    • signs of low blood
      pressure (e.g., dizziness, lightheadedness)
    • signs of muscle
      breakdown (e.g., muscle weakness, pain, bruising, confusion)
    • suddenly falling
    • unusual and
      uncontrolled muscle movement of the body (including face, tongue, arms,
      hands, head, upper body)
    • unusual tiredness or
    • unusual weight gain or
    • vision changes (e.g.,
      blurred vision, dilated (large) pupils, double-vision)
    • worsening symptoms of
      Parkinson’s disease

    Stop taking the medication and seek immediate medical attention if any of the following occur:

    • signs of heart attack (e.g.,
      sudden chest pain or pain radiating to back, down arm, or jaw; sensation
      of fullness of the chest; nausea; vomiting; sweating; anxiety)
    • signs of neuroleptic
      malignant syndrome (e.g., agitation; anxiety; confusion; fast, irregular,
      or pounding heartbeat; increased body temperature; muscle rigidity)
    • signs of a severe skin
      reaction (i.e., blistering, peeling, a rash covering a large area of the
      body, a rash that spreads quickly, or a rash combined with fever or
    • signs of a serious allergic
      reaction (i.e., abdominal cramps, difficulty breathing, rash, hives, or
      swelling of the face and throat)

    Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are
    taking this medication.

    Are there any other precautions or warnings for this medication?

    Before you begin taking a medication, be sure to inform your doctor of
    any medical conditions or allergies you may have, any medications you are
    taking, whether you are pregnant or breast-feeding, and any other significant
    facts about your health. These factors may affect how you should take this

    Behavioural and mood changes: This medication may cause mood and
    psychiatric changes, including hallucinations, hypersexuality, pathological gambling,
    and increased libido. Tell your doctor as soon as possible if you notice any
    unusual changes in your behaviour, have thoughts of harming yourself, or feel

    If you have depression or a history of depression, discuss with your doctor
    how this medication may affect your medical condition, how your medical
    condition may affect the dosing and effectiveness of this medication, and
    whether any special monitoring is needed. If you experience symptoms of
    depression such as poor concentration, changes in weight, changes in sleep,
    decreased interest in activities, or notice them in a family member who is
    taking this medication contact your doctor as soon as possible.

    Diarrhea: Diarrhea is a common side effect of this medication. It may
    appear as early as the first week of starting treatment or many months after
    starting treatment. For some people, the diarrhea causes weight loss. If you
    notice any weight loss or have excessive diarrhea, contact your doctor.

    Dizziness/reduced alertness: This medication may cause low blood
    pressure or dizziness and lightheadedness when rising from a lying or sitting
    position. People taking medications that can cause dizziness should rise slowly
    from sitting or lying down to reduce the possibility of severe dizziness or fainting.
    Do not drive, operate machinery, or perform other hazardous tasks until you
    have determined how this medication affects you.

    Fructose intolerance: This medication contains fructose. If you have
    fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase
    insufficiency, you should not take this medication. Talk to your doctor.

    Heart disease: This medication may cause an increase in the risk of
    heart attack or heart disease. If you have a history of heart disease, discuss
    with your doctor how this medication may affect your medical condition, how
    your medical condition may affect the dosing and effectiveness of this
    medication, and whether any special monitoring is needed.

    Liver function: Liver disease or reduced liver function may cause
    this medication to build up in the body, causing side effects. This medication
    is not recommended for people with liver problems.

    Melanoma: People with Parkinson’s disease may be at increased risk of
    developing melanoma (a type of skin cancer). It is not known if this increased
    risk is due to Parkinson’s disease or to the medications used to treat
    Parkinson’s disease. Your doctor will monitor you for skin cancer while you are
    taking this medication. Talk to your doctor if you have any concerns.

    Neuroleptic malignant syndrome (NMS): This medication may cause a
    potentially fatal reaction called neuroleptic malignant syndrome (NMS). If you
    develop symptoms of NMS, such as muscle stiffness, fever, confusion, sweating,
    or irregular heartbeat, stop taking this medication and seek immediate medical

    Prostate Cancer: A recent study has shown an increase in the number
    of cases of prostate cancer among men who have taken levodopa/carbidopa with or
    without entacapone for approximately 3 years. Although it is not clear whether
    this increased risk of prostate cancer is due to the medication or something
    else, it is important to have regular prostate examinations while taking
    medications for Parkinson’s Disease.

    Rhabdomyolysis (muscle breakdown): Occasionally, this medication may
    cause rapid breakdown of muscle tissue. If you notice signs of muscle weakness
    or pain, high body temperature, unexpected bruising, confusion, or difficulty
    passing urine, contact your doctor immediately.

    Stopping this medication: Stopping this medication too quickly can
    cause potentially life-threatening side effects. Before stopping this
    medication, discuss the risks and benefits with your doctor. Do not stop taking
    this medication until you have spoken with your doctor first.

    Sudden onset of sleep: There are reports of people who take this
    combination medication treatment (entacapone with levodopa – carbidopa) falling
    asleep without prior warning or drowsiness. If you have a sleep disorder,
    discuss this with your doctor. If you experience drowsiness while taking this
    medication, avoid driving or using machinery.

    Pregnancy: This medication should not be used during pregnancy unless
    the benefits outweigh the risks. If you become pregnant while taking this
    medication, contact your doctor immediately.

    Breast feeding: It is not known if entacapone passes into breast
    milk. If you are a breast-feeding mother and are using this medication, it may
    affect your baby. Talk to your doctor about whether you should continue

    Children: The safety and effectiveness of using this medication have
    not been established for children less than 18 years of age.

    What other drugs could interact with this medication?

    There may be an interaction between entacapone and any of the following:

    • alcohol
    • antihistamines (e.g.,
      chlorpheniramine, diphenhydramine, hydroxyzine)
    • anti-seizure
      medications (e.g., carbamazepine, gabapentin, lamotrigine, phenytoin,
    • antipsychotics (e.g.,
      fluphenazine, perphenazine, quetiapine, risperidone)
    • apomorphine
    • azelastine
    • baclofen
    • barbiturates (e.g.,
      butalbital, phenobarbital)
    • benzodiazepines (e.g.,
      alprazolam, diazepam, lorazepam)
    • brimonidine
    • buprenorphine
    • buspirone
    • chloral hydrate
    • dobutamine
    • dopamine
    • droperidol
    • epinephrine
    • iron supplements
    • isoproterenol
    • linezolid
    • magnesium sulfate
    • MAO inhibitors (e.g.,
      moclobemide, phenelzine, rasagiline, selegiline,
    • methotrimeprazine
    • methyldopa
    • mirtazapine
    • muscle relaxants
      (e.g., cyclobenzaprine, methocarbamol, orphenadrine)
    • narcotic medications
      (e.g., codeine, fentanyl, morphine)
    • norepinephrine
    • paraldehyde
    • pimozide
    • pramipexole
    • procarbazine
    • ropinirole
    • selective serotonin
      reuptake inhibitors (e.g., citalopram, fluoxetine, paroxetine,
    • tapentadol
    • tramadol
    • tricyclic
      antidepressants (e.g., amitriptyline, clomipramine, desipramine,
    • warfarin
    • zolpidem
    • zopiclone

    If you are taking any of these medications, speak with your doctor or
    Depending on your specific circumstances, your doctor may want
    you to:

    • stop taking one of the
    • change one of the medications
      to another,
    • change how you are taking one
      or both of the medications, or
    • leave everything as is.

    An interaction between two medications does not always mean that you must
    stop taking one of them.
    Speak to your doctor about how any drug
    interactions are being managed or should be managed.

    Medications other than those listed above may interact with this
    Tell your doctor or prescriber about all prescription,
    over-the-counter (non-prescription), and herbal medications you are taking.
    Also tell them about any supplements you take. Since caffeine, alcohol, the
    nicotine from cigarettes, or street drugs can affect the action of many
    medications, you should let your prescriber know if you use them.

    All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:

    All material © 1996-2018 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.