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  • All material © 1996-2015 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.



    Common Name

    chlordiazepoxide – clidinium

    How does this medication work? What will it do for me?

    Chlordiazepoxide belongs to the class of medications called benzodiazepines. Clidinium belongs to the class of medications called anticholinergics. Chlordiazepoxide and clidinium are a combination of medications used to treat stomach and intestinal problems such as irritable bowel syndrome (IBS) and ulcers.

    Chlordiazepoxide – clidinium helps by reducing the amount of acid formed in your stomach as well as by relieving the pain of stomach spasms and abdominal cramps. Often, relief from symptoms occurs with the first couple of doses.

    This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

    Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

    Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

    What form(s) does this medication come in?

    Each green opaque, No. 4 capsule contains chlordiazepoxide HCl 5 mg and clidinium bromide 2.5 mg. Nonmedicinal ingredients: lactose, microcrystalline cellulose, stearic acid, and talc; capsule: D&C Yellow No. 10, edible black ink (black iron oxide; may contain pharmaceutical glaze, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, D&C Yellow No. 10 Aluminum Lake, n-butyl alcohol, propylene glycol, SDA-3A alcohol, pharmaceutical shellac, ethyl alcohol, isopropyl alcohol, ammonium hydroxide, and potassium hydroxide), FD&C Blue No. 1, FD&C Yellow No. 6, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide.

    How should I use this medication?

    The recommended adult dose of this medication is 1 or 2 capsules taken 1 to 4 times a day. The capsules should be taken 30 to 60 minutes before a meal, unless otherwise instructed by your doctor. For seniors, the dose should start at 1 capsule 2 times a day, with adjustment to the dose as needed and tolerated. It is important that the dose be individualized to your specific needs to avoid excessive sedation or motor impairment.

    This medication may be habit-forming when taken for long periods of time. If you have been taking this medication regularly for a long period of time (i.e., more than 1 month), do not stop taking the medication without first speaking with your doctor. To avoid withdrawal effects, a gradual dose reduction is usually recommended when stopping this medication.

    Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

    It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If your next dose is in less than 4 hours, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

    Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

    Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

    Who should NOT take this medication?

    Chlordiazepoxide – clidinium should not be taken by anyone who:

    • is allergic to clidinium, chlordiazepoxide, any other medications belonging to the benzodiazepine class, or to any of the ingredients of the medication
    • is breast-feeding
    • is pregnant or planning to become pregnant
    • has a hiatus hernia with reflux esophagitis
    • has a history of drug abuse or dependence
    • has an enlarged prostate
    • has active heart problems
    • has difficulty urinating
    • has glaucoma
    • has intestinal atony (“lazy bowel”)
    • has liver disease
    • has myasthenia gravis
    • has ulcerative colitis
    What side effects are possible with this medication?

    Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

    The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

    Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

    • bloated feeling
    • decreased sweating
    • dizziness
    • drowsiness
    • dry mouth
    • headache

    Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

    Check with your doctor as soon as possible if any of the following side effects occur:

    • constipation
    • eye pain
    • insomnia
    • mental depression
    • nervousness or irritability
    • shortness of breath
    • skin rash or hives
    • slow heartbeat
    • sore throat and fever
    • unusual excitement
    • yellow eyes or skin

    Stop taking the medication and seek immediate medical attention if any of the following occur:

    • confusion
    • difficult urination
    • drowsiness (severe)
    • dryness of nose, mouth, throat (severe)
    • fast heartbeat
    • unusual warmth, dryness, and flushing of skin

    Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

    Are there any other precautions or warnings for this medication?

    Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

    Dental problems: Since one of the ingredients may cause a dry mouth, there is an increase risk of dental disease.

    Dependence and withdrawal: Physical dependence (a need to take regular doses to prevent physical symptoms) has been associated with benzodiazepines such as chlordiazepoxide – clidinium. Severe withdrawal may occur if the dose is significantly reduced or suddenly discontinued. These symptoms include seizures, irritability, nervousness, sleep problems, agitation, tremors, diarrhea, abdominal cramps, vomiting, memory impairment, headache, muscle pain, extreme anxiety, tension, restlessness, and confusion. Reducing the dose gradually under medical supervision can help prevent or decrease these withdrawal symptoms.

    Drowsiness/reduced alertness: Because chlordiazepoxide – clidinium may cause drowsiness and sedation, do not engage in activities that require mental alertness, judgment, and physical coordination (such as driving or operating machinery) while taking this medication. This is particularly true when first starting the medication and until you have established that chlordiazepoxide – clidinium does not affect you this way. Alcohol ingestion can increase the drowsiness effects and should be avoided.

    Medical conditions: Tell your doctor if you have any of the following conditions, as it may influence whether your doctor recommends this medication:

    • chronic obstructive pulmonary disease (COPD)
    • depression
    • glaucoma (open-angle)
    • hiatus hernia
    • high blood pressure
    • intestinal blockage
    • kidney disease
    • liver disease
    • mental illness
    • myasthenia gravis
    • overactive thyroid
    • ulcerative colitis
    • xerostomia (condition with severe loss of saliva)

    People with an addiction to alcohol or other medications should not take chlordiazepoxide, except in rare situations under medical supervision.

    Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks.

    Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are taking chlordiazepoxide – clidinium, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

    Children: The safety and effectiveness of using this medication have not been established for children.

    Seniors: Seniors may be at increased risk for the sedative and impaired coordination effects of this medication. They need to use extra caution, for example, when getting up during the night.

    What other drugs could interact with this medication?

    There may be an interaction between chlordiazepoxide – clidinium and any of the following:

    • alcohol
    • antacids
    • anticholinergic medications (e.g., atropine, hyoscyamine)
    • clarithromycin
    • diarrhea medicines that contain kaolin or attapulgite
    • fluconazole
    • fluvoxamine
    • itraconazole
    • ketoconazole
    • medications that cause sedation (e.g., antidepressants, benzodiazepines, barbiturates, MAO inhibitors, narcotics, phenothiazines, antihistamines)
    • nefazodone
    • phenytoin
    • potassium chloride
    • theophylline
    • warfarin

    If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

    • stop taking one of the medications,
    • change one of the medications to another,
    • change how you are taking one or both of the medications, or
    • leave everything as is.

    An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

    Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

    All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:

    All material © 1996-2018 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.