Endocarditis is an inflammation of the lining of the heart valves that is most often caused by infection. Most people who develop this condition already have heart problems and are over 60 years old, but it can occur at any age, including in children. While not very common, this can be a very serious disease. Men are more likely to be affected than women.
There are two types of endocarditis: infective and non-infective. With prompt treatment, the majority of people with infective endocarditis will survive. Non-infective endocarditis is more difficult to treat.
Some people are more likely than others to develop endocarditis. The following conditions increase the risk:
Endocarditis develops in the endocardium, the inner tissue of the heart. It starts if this tissue has been damaged, injured, or infected. Much as a cut on the skin causes a scab to form, damage to the endocardium can lead to the formation of a blood and tissue clot (thrombus).
In acute infective endocarditis, the clots are caused by bacterial or fungal infection, inflaming and damaging the heart cells. The infection reaches the heart through blood that’s carrying a concentration of bacteria, a condition called bacteremia. Once the infectious agent reaches the heart via the blood, it tends to concentrate around the valves – the blood’s point of entry and exit. Despite the name, infective endocarditis isn’t contagious.
The infecting agent can get into the blood through:
In non-infective endocarditis, the clot may not be infected but interferes with heart valve function anyway. Some conditions make the formation of scar tissue on the heart valves more likely:
Endocarditis can start slowly and gradually, over the course of several months. This is called subacute infective endocarditis. Symptoms include:
If the disease goes untreated for some time, further symptoms may appear:
tiny blood clots under the finger or toenails (splinter hemorrhages)At other times, infection progresses very quickly. This is known as acute endocarditis, and causes:
Although most people with infectious endocarditis have a fever, older people and those with long-lasting (chronic) conditions like kidney disease or congestive heart failure may not.
Only your doctor can diagnose endocarditis. The heart test known as an echocardiogram is the main tool for diagnosing endocarditis. For an echocardiogram, a special gel is spread on your chest and a transducer (a device that emits high frequency waves) is put on the chest and moved around. The waves put out by the transducer bounce off different structures in your heart and allow the doctor to see your heart and how it is functioning. Another type of echocardiogram, a transesophageal echocardiogram or TEE, is performed by passing a tube through the esophagus, or food pipe, to take close-up pictures of the heart valves.
If endocarditis is found, you’ll need blood tests to identify any bacteria or fungi. This is vital because the treatment for non-infective endocarditis is different than for infective endocarditis.
If a bacterium is causing endocarditis, your doctor will prescribe one or more antibiotics for 2 to 8 weeks. These antibiotics often have to be given by intravenous (IV) injection. If a fungus is the cause, an antifungal medication is given. These must usually be given by IV injection for 6 or more weeks. Heart surgery is sometimes needed for infective endocarditis, especially for people with prosthetic heart valves.
Non-infective endocarditis is treated with anticoagulants like warfarin* that help prevent further clots from developing.
To prevent infective endocarditis, be sure to let your doctor know if you have a prosthetic valve, have previously had endocarditis or have congenital heart disease. This is important especially if you need to undergo surgery or dental work. If you are at a high risk for endocarditis, you may be prescribed antibiotics before surgery or dental work to reduce the risk of endocarditis, depending on the type of procedure you will be undergoing. It is extremely important to take these antibiotics as directed by your doctor.
Currently, recommended preventative antibiotics for dental procedures include:
There are some other preventive measures you can take:
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