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  • All material © 1996-2015 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.



    Common Name

    fexofenadine – pseudoephedrine

    How does this medication work? What will it do for me?

    This is a combination medication that contains two ingredients: fexofenadine and pseudoephedrine. Pseudoephedrine belongs to a group of medications called decongestants. Pseudoephedrine works by clearing and draining the nasal passages and sinuses. Fexofenadine belongs to a group of medications called antihistamines. During an allergic reaction, the body produces a chemical called histamine, which causes allergy symptoms. These allergy symptoms include sneezing, runny nose, itchy throat, and watery eyes. Fexofenadine works by blocking the action of histamine in the body to reduce allergy symptoms.

    Together, fexofenadine and pseudoephedrine work to relieve the symptoms associated with allergic rhinitis, including nasal and sinus congestion, sneezing, runny nose, itchy nose, and throat irritation, as well as red, itchy, and watery eyes.

    Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

    Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

    What form(s) does this medication come in?

    Each caplet engraved with “06/012D” on the white layer contains fexofenadine HCl 60 mg and pseudoephedrine HCl 120 mg. Available as a bilayer clear film coated caplet (capsule-shaped tablet) with one half (lengthwise) white to off-white and the other half tan. The fexofenadine layer is an immediate-release formulation; the pseudoephedrine layer is a sustained-release formulation. Nonmedicinal ingredients: carnauba wax, cornstarch, croscarmellose sodium, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, silicon dioxide, and stearic acid.

    How should I use this medication?

    For adults and children 12 years of age and older, the usual dose is one caplet twice daily. People with poor kidney function may be prescribed a lower dose by their doctor (i.e., one caplet once daily).

    Take this medication on an empty stomach. Do not take this medication within 2 hours of taking an antacid that contains aluminum or magnesium.

    Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

    It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

    Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

    Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

    Who should NOT take this medication?

    Fexofenadine – pseudoephedrine should not be taken by anyone who:

    • is allergic to fexofenadine, pseudoephedrine, or to any of the ingredients of the medication
    • has narrow-angle glaucoma, urinary retention, severe high blood pressure, or severe coronary artery disease
    • has taken monoamine oxidase (MAO) inhibitors within 14 days or who intends to take such a medication during that timeframe
    What side effects are possible with this medication?

    Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

    The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

    Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

    • dizziness
    • dry mouth
    • headache
    • heartburn
    • nausea
    • nervousness
    • throat irritation
    • trouble sleeping

    Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

    Check with your doctor as soon as possible if any of the following side effects occur:

    • anxiety
    • irregular or rapid heartbeat
    • nervousness, agitation, or restlessness
    • shakiness or tremor

    Stop taking the medication and seek immediate medical attention if any of the following occur:

    • convulsions
    • difficulty breathing
    • hallucinations
    • skin rash
    • swelling of face or throat

    Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

    Are there any other precautions or warnings for this medication?

    Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

    Kidney disease: People with kidney disease should receive a lower dose because the medication will not be cleared from the body as quickly.

    Medical conditions: Decongestants such as pseudoephedrine should be used with caution by people with:

    • a hyperactive response to ephedrine
    • diabetes
    • enlarged prostate
    • glaucoma
    • heart disease
    • high blood pressure
    • high intraocular (inside the eye) pressure
    • kidney disease
    • overactive thyroid
    • stomach ulcers

    Pregnancy: It is not known if this medication is safe to use during pregnancy. It should not be used during pregnancy unless the potential benefits outweigh the risks.

    Breast-feeding: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

    Children: The safety and effectiveness of this medication have not been established for children under 12 years of age.

    Seniors: Seniors should use this medication with caution, as they are more likely to experience the side effects of pseudoephedrine.

    What other drugs could interact with this medication?

    There may be an interaction between fexofenadine – pseudoephedrine and any of the following:

    • antacids containing both aluminum and magnesium
    • appetite suppressants
    • blood pressure medications
    • digoxin
    • MAO inhibitors (e.g., phenelzine, tranylcypromine)
    • other decongestants
    • stimulants (e.g., methylphenidate, dextroamphetamine)

    If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

    • stop taking one of the medications,
    • change one of the medications to another,
    • change how you are taking one or both of the medications, or
    • leave everything as is.

    An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

    Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

    All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:

    All material © 1996-2018 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.