Jaundice is a symptom of many medical problems but it is most often associated with conditions of the liver or the gallbladder. Jaundice causes yellow skin and eyes because of an excess amount of the bile pigment bilirubin in the fat layer under the skin. Either the body is producing too much, or it’s not getting rid of it fast enough.
In addition to being caused by problems with the liver, jaundice can also occur among newborns, particularly premature babies. Jaundice that occurs at the time of birth generally disappears within days, but some babies require phototherapy treatment (special lights that help break down bilirubin). In this case, the yellowing of the skin is not due to liver or gallbladder disease.
Instead, jaundice is caused by the fact that fetuses have a different kind of red blood cell than adults. They are just getting rid of these cells around the time of birth, which releases a lot of bilirubin. Newborns also temporarily lack sufficient amounts of the enzymes that break down bilirubin. With time, the liver cells mature and are able to rid the body of excess bilirubin, and the jaundice will disappear.
Normally, large amounts of blood flow each minute through the liver, which may be thought of as the body’s chemical processing plant. The liver breaks down old, inefficient red blood cells in a process called hemolysis. This releases large amounts of bilirubin. The liver also manufactures the other components of bile.
Bile is a greenish-yellow fluid secreted by the liver that contains cholesterol, bile salts, and waste products such as bilirubin. The bilirubin leaves the liver via the bile ducts to be stored in the gallbladder directly underneath. It’s then slowly released into the intestine from the gallbladder. It helps digest food in the intestine and exits the body in the stool.
Too much bilirubin can be toxic and can cause jaundice. Therefore, it’s important to eliminate it from the body as fast as it’s produced. There are three basic ways this process can go wrong:
Some causes of jaundice due to poor liver function include:
Some causes of jaundice due to obstruction (blockage) include:
Some causes due to excessive red blood cell destruction (hemolysis):
When you are jaundiced, your skin and the whites of your eyes are yellow. Sometimes, people who eat a lot of carrots or beta-carotene tablets take on a yellowish colour. This is called carotenemia, and can be easily distinguished from jaundice because the whites of the eyes don’t turn yellow.
Other symptoms depend on the cause of jaundice. If a fever or flu-like illness comes before jaundice, it’s usually a sign of a viral hepatitis infection. Brown urine, common in hepatitis, is generally a sign of poor liver function or increased red blood cell destruction. The body is trying to get rid of excess bilirubin in the urine. Pale, white, or clay-coloured stool, on the other hand, is an indicator of obstruction in the gallbladder or bile ducts. Many people with obstruction due to gallstones experience abdominal pain, while those with obstruction due to tumours usually have painless jaundice.
Jaundice itself is unlikely to hurt you unless the bilirubin reaches very high concentrations. It is a sign, however, of an underlying problem. There are too many possible causes of jaundice to attempt diagnosis at home. You should see a doctor if you think you have jaundice.
Your doctor will take a medical history and perform a physical exam. Your doctor will ask how suddenly the jaundice came on, what other symptoms accompanied it, and how the stool and urine look. A blood sample will also be taken and checked for hepatitis virus antibodies, abnormal red blood cells, bilirubin levels, and various other substances that give clues about liver function. Your doctor may also order other tests such as an ultrasound or biopsy to determine the cause of jaundice.
There’s no treatment for jaundice as such, since it’s not a disease but a sign of a medical problem. The approach is to treat the underlying cause, if possible. Some of the medical problems that cause jaundice are curable, like malaria. Others, like thalassemia, are treatable. Many, like hepatitis A, newborn jaundice, or cholestasis of pregnancy, aren’t curable but go away on their own. Usually treatment is unnecessary. Conditions like cirrhosis and chronic hepatitis are lifelong problems that may cause permanent or recurring jaundice. Some types of cancer can cause jaundice and should be investigated by a physician as early as possible, since early detection and treatment can improve survival.
Many of these diseases are inherited or autoimmune conditions that we don’t know how to prevent. People can, however, do something about the two most common causes of jaundice – viral hepatitis and alcoholic liver disease. There are vaccines against hepatitis A and B (although, unfortunately, not against type C). The hepatitis B vaccine can protect you against lifelong complications of this disease. People suffering from alcoholism can help reduce their risk of alcoholic liver disease by seeking treatment for their condition.
All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/condition/getcondition/Jaundice